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Sunday heralds the initial Wear-Tyne derby after 2024, but which side will celebrate – the Black Cats or Newcastle?
"For most of last season, it was unthinkable Sunderland rising to the top flight and challenging with Eddie Howe's Newcastle, never mind being above them in the table," remarked football expert Chris Sutton.
"It is very different now, and the way Sunderland play leads me to believe they've got a genuine opportunity."
The analyst is providing predictions for all 380 Premier League games this season, in competition with AI, fans and a assortment of guests.
For week 16, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is competing for honours for the eLions – the Football Association's official esports team – at the football simulation European esports championship finals tournament, which will occur at Twickenham Stadium on Saturday.
Viewers can catch Uefa's video platform, Instagram Live and short-form video channels, as well as the official Twitch channel and YouTube and England's Twitch.
Do you agree with their predictions? Feel free to submit your own guesses below.
The most popular scoreline chosen for each game is featured in the leaderboards at the end of this page.
Predicting the right outcome (selecting a win, draw or defeat) is worth 10 points. A perfect prediction earns forty points.
Ray, who competes for his club side and the Premier League champions as well as England, is entering the fray at the eEuros finals after getting through the qualifying.
A group of eight will play for their countries at the finals in a single-elimination, vying for a substantial cash prize and a prestigious spot in the global championship qualifiers, with the Danish representative Anders Vejrgang looking to retain the title he won last year.
"My mindset is really good for it," Ray said. "There's a really good coach by my side and preparation has been going well.
"It is invariably an honour to play for your country. Of course when you are younger, you fantasise about doing it as an professional footballer, but when you pursue a career in this job and there is an opportunity to represent England, donning the national jersey is something unique.
"I overcame Vejrgang 9-4 in qualifying to get here. I've played against him throughout the year just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"In my opinion he is the best player in the world so defeating him in a tournament like this just delivers a massive injection of confidence."
Premier League Predictions
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
Chelsea were outstanding against the Gunners at the end of November, when they got a draw after going down to 10 men, and many thought here we go, they could potentially be challengers for the crown.
In the matches following, however, they were outfought by Leeds, looked lethargic against Bournemouth and this week got turned over by Atalanta in the Champions League.
So head coach Enzo Maresca desperately requires a win here to return to winning ways, but it will be a challenge because the Merseyside club are such a potent team.
Two of their stars are playing really well and they have got a bit of form at the moment.
Current evidence suggests you would probably back the visitors, while the most sensible prediction would probably be a draw, but I'm throwing caution to the wind.
Chelsea haven't given me any good cause to back them recently, but I just have a hunch Chelsea will take this one because they are at home and they are overdue a victory.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I am at this game and it will be intriguing to see what we get from the Reds.
I am really pleased for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday after all the controversy with Mohamed Salah this week.
Slot should not have to put up with that nonsense. I know Salah has been a legend for Liverpool but at its core Slot just wants to win games and there is no bias in his team selection.
Liverpool changed their formation against Inter and went with a midfield diamond formation and two up top.
The media is going to be talking about whether Salah is back for this game, but the only way he is going to be brought back into the fold is if he says sorry.
Slot's primary concern will be on winning this game, but it is a difficult fixture.
It's fair to say it is the same for most teams but I find Brighton so hard to predict. I always feel they have got a goal in them, but they are quite open too.
Liverpool need to get back to stringing wins together, but I am not sure how much their efforts at the San Siro will have affected their stamina.
I put a couple of Brighton players in my FPL team, so they will probably lose now - but I do fancy them to get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Black Cats have had the week off while Newcastle had to battle intensely against Bayer Leverkusen on Wednesday, only to let their lead slip away late on.
Apart from their excellent performance against Everton a couple of weeks ago, Newcastle's away form has been inconsistent, especially straight after they've played in the Champions League.
It is anticipated that that pattern to continue on Sunday, and their fatigue is likely to be a significant issue in how this game goes because of Sunderland's high press.
We saw how unwavering Regis le Bris's side are. They dominated the Gunners, and it was incredible to watch.
Many pundits talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been superb, but Noah Sadiki, who plays alongside him, has also been one of the signings of the season and should be recognised too.
This promises to be this being the best game|most exciting fixture